SYSTEMATIC DISSECTION AND TRAJECTORY-SCANNING MUTAGENESIS OF THE MOLECULAR INTERFACE THAT ENSURES SPECIFICITY OF TWO-COMPONENT SIGNALING PATHWAYS.

Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways.

Two-component signal transduction systems enable bacteria to sense and respond to a wide range of environmental stimuli.Sensor histidine kinases transmit signals to their cognate response regulators via phosphorylation.The faithful transmission of information through two-component pathways and the avoidance of unwanted cross-talk require exquisite

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Case Report of Concomitant Diagnosis of Locally Advanced Intrahepatic Cholangiocarcinoma and Solitary Plasmacytoma of T11 Vertebra: Impact on Diagnostic and Clinical Management

A solitary bone plasmacytoma is a rare tumor.Intrahepatic cholangiocarcinoma is the second most common primary liver cancer after hepatocellular carcinoma.We present the case of a 48-year-old female patient who consulted for recent back pain, with a final diagnosis of T10 solitary plasmacytoma and synchronous intrahepatic cholangiocarcinoma.Imaging

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